Open AccessMutation-induced DNMT1 cleavage drives neurodegenerative disease
Author(s) -
Wencai Wang,
Xingsen Zhao,
Yanjiao Shao,
Xiaoya Duan,
Yaling Wang,
Jialun Li,
Jiwen Li,
Dali Li,
Xuekun Li,
Jiemin Wong
Publication year - 2021
Publication title -
science advances
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abe8511
Subject(s) - mutant , dnmt1 , mutation , biology , genetics , mutant protein , microbiology and biotechnology , cleavage (geology) , gene , methyltransferase , paleontology , methylation , fracture (geology)
Using mouse and cell models, this study reveals the key mechanism for DNMT1 RFTS mutation–induced neurodegenerative diseases.
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