Open AccessThe deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis
Author(s) -
Fei Yi,
Ying Zhang,
Zhijun Wang,
Zhuo Wang,
Ziwei Li,
Tingting Zhou,
Hongde Xu,
Jingwei Liu,
Bo Jiang,
Xiaoman Li,
Liang Wang,
Ning Bai,
Qiqiang Guo,
Yi Guan,
Yanling Feng,
Zhiyong Mao,
Guangjian Fan,
Shengping Zhang,
Chuangui Wang,
Longyue L. Cao,
Brian O’Rourke,
Yang Wang,
Yanmei Wu,
Boquan Wu,
Shilong You,
Naijin Zhang,
JunLin Guan,
Xiaoyu Song,
Yingxian Sun,
Shi Wei,
Liu Cao
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abe5518
Subject(s) - sirt2 , mitotic catastrophe , acetylation , mitosis , biology , carcinogenesis , microbiology and biotechnology , epigenetics , phosphorylation , sirtuin , cell cycle , cancer research , genetics , cell , cancer , gene
SIRT2-mediated deacetylation of SMC1A promotes its phosphorylation and overcomes the oncogenic stress for tumor cell survival.
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