Open AccessImaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis
Author(s) -
Capucine L. Grandjean,
Zacarias Garcia,
Fabrice Lemaı̂tre,
Béatrice Breart,
Philippe Bousso
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abd6167
Subject(s) - phagocytosis , in vivo , bone marrow , cancer research , antibody , apoptosis , cd20 , cytotoxicity , efferocytosis , biology , chemistry , immunology , microbiology and biotechnology , macrophage , in vitro , biochemistry
The mechanism and limitations of anti-CD20 therapy, a major treatment for B cell lymphomas, were uncovered using in vivo imaging.
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