Open AccessA stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection
Author(s) -
Anika Kuster,
Nour L. Mozaffari,
Oliver J. Wilkinson,
Jessica L. Wojtaszek,
Christina Zurfluh,
Sara Przetocka,
Dawid Zyla,
Christine von Aesch,
Mark S. Dillingham,
R. Scott Williams,
Alessandro A. Sartori
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abc6381
Subject(s) - microbiology and biotechnology , dna damage , dna repair , dna replication , chromatin , biology , homologous recombination , dna , chemistry , cancer research , biochemistry
A stapled peptide targets CtIP tetramers to inhibit DNA repair and exert synthetic lethality in BRCA1-mutant cancer cells.
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