Open AccessReengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability
Author(s) -
Marian H. Hettiaratchi,
Matthew J. O’Meara,
Teresa R. O’Meara,
Andrew Pickering,
Nitzan Letko-Khait,
Molly S. Shoichet
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abc6378
Subject(s) - mutant , chemistry , homology modeling , computational biology , biology , biochemistry , enzyme , gene
Computational redesign of chondroitinase ABC introduces 37 point mutations to improve enzyme stability and activity.