Open AccessNoncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease
Author(s) -
Bradlee L. Heckmann,
Brett J.W. Teubner,
Emilio Boada-Romero,
Bart Tummers,
Clifford S. Guy,
Patrick Fitzgerald,
Ulríke Mayer,
Simon R. Carding,
Stanislav S. Zakharenko,
Thomas Wileman,
Douglas R. Green
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abb9036
Subject(s) - autophagy , function (biology) , disease , microbiology and biotechnology , alzheimer's disease , neuroscience , biology , chemistry , medicine , biochemistry , pathology , apoptosis
Mice with mutant ATG16L develop spontaneous, severe Alzheimer’s-like disease with age, despite normal autophagy.
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