Open AccessA nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems
Author(s) -
Yiming Cai,
B. F. Usher,
Claude Gutierrez,
Anastasia Tolcan,
Moïse Mansour,
Peter C. Fineran,
Ciarán Condon,
Olivier Neyrolles,
Pierre Genevaux,
Tim R. Blower
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abb6651
Subject(s) - nucleotidyltransferase , transfer rna , mycobacterium tuberculosis , toxin , microbiology and biotechnology , virology , biology , chemistry , tuberculosis , biochemistry , rna , medicine , gene , pathology
The human pathogenMycobacterium tuberculosis produces a toxin that can stall bacterial growth by blocking the activity of tRNAs.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom