Open AccessFlux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway
Author(s) -
Harry Kemble,
Catherine Eisenhauer,
Alejandro Couce,
Audrey Chapron,
Mélanie Magnan,
Grégory Gautier,
Hervé Le Nagard,
Philippe Nghe,
Olivier Tenaillon
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abb2236
Subject(s) - flux (metallurgy) , computational biology , toxicity , expression (computer science) , biology , metabolic pathway , genetics , bioinformatics , evolutionary biology , computer science , chemistry , gene , organic chemistry , programming language
Complex fitness interactions between alleles and expression-modulating environment are explained by a simple metabolic model.
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