Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor | Zendy

Dan Yue | Zendy; Zhujun Chen | Zendy; Fanli Yang | Zendy; Fei Ye | Zendy; Sheng Lin | Zendy; Bin He | Zendy; Yanwei Cheng | Zendy; Jichao Wang | Zendy; Zimin Chen | Zendy; Xi Lin | Zendy; Jing Yang | Zendy; Hua Chen | Zendy; Zhonglin Zhang | Zendy; You Yu | Zendy; Honglu Sun | Zendy; Ao Wen | Zendy; Lingling Wang | Zendy; Yue Zheng | Zendy; Yu Cao | Zendy; Yuhua Li | Zendy; Guangwen Lu | Zendy

Open Access

Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor

Author(s) -

Dan Yue,

Zhujun Chen,

Fanli Yang,

Fei Ye,

Sheng Lin,

Bin He,

Yanwei Cheng,

Jichao Wang,

Zimin Chen,

Xi Lin,

Jing Yang,

Hua Chen,

Zhonglin Zhang,

You Yu,

Honglu Sun,

Ao Wen,

Lingling Wang,

Yue Zheng,

Yu Cao,

Yuhua Li,

Guangwen Lu

Publication year - 2020

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aba5147

Subject(s) - nectin , receptor , bovine herpesvirus 1 , glycoprotein , binding site , steric effects , virus , conformational change , biology , chemistry , virology , stereochemistry , biophysics , microbiology and biotechnology , biochemistry , cell , cell adhesion , herpesviridae , viral disease

BHV-1 gD structures reveal that viral ligand has a unique G-strand/α2-helix interloop interfering with nectin-1 binding.

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