Open AccessDisruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest
Author(s) -
Aijie Xin,
Ronggui Qu,
Guowu Chen,
Ling Zhang,
Junling Chen,
Chengqiu Tao,
Jing Fu,
Jianan Tang,
Yanfei Ru,
Ying Chen,
Xiandong Peng,
Huijuan Shi,
Feng Zhang,
Xiaoxi Sun
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaz4796
Subject(s) - ultrastructure , sperm , embryonic stem cell , microbiology and biotechnology , biology , andrology , embryo , embryogenesis , anatomy , medicine , genetics , gene
ACTL7A deficiency is a novel male factor inducing early embryonic arrest that can be overcome by artificial oocyte activation.
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