Open AccessComputer simulations explain mutation-induced effects on the DNA editing by adenine base editors
Author(s) -
Kartik L. Rallapalli,
Alexis C. Komor,
Francesco Paesani
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaz2309
Subject(s) - base (topology) , mutation , computer science , dna , computational biology , base pair , genetics , biology , mathematics , gene , mathematical analysis
We uncovered structural and functional changes induced by mutations that dictate the DNA editing activity of ABE enzymes.
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