Open AccessDUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation
Author(s) -
Ruining Ma,
Lina Ma,
Weiji Weng,
Yingping Wang,
Huiqing Liu,
Rongjun Guo,
Yingwei Gao,
Jun Tu,
TianLe Xu,
Jinke Cheng,
Michael X. Zhu,
Aiwu Zhou,
Yong Li
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaz0361
Subject(s) - dephosphorylation , sumo protein , phosphorylation , dusp6 , microbiology and biotechnology , apoptosis , phosphatase , mitochondrion , kinase , ubiquitin , biology , mitochondrial fission , chemistry , biochemistry , protein phosphatase 2 , gene
Our work uncovers a novel SUMOylation-dependent regulation of DUSP6 stability and its activity, which regulates Drp1 function.
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