Open AccessThe clonal repopulation of HSPC gene modified with anti–HIV-1 RNAi is not affected by preexisting HIV-1 infection
Author(s) -
Gajendra W. Suryawanshi,
Wannisa Khamaikawin,
Jing Wen,
Saki Shimizu,
Hubert Arokium,
Yiming Xie,
Eugene Wang,
Shihyoung Kim,
Hyewon Choi,
Chong Zhang,
Hannah Yu,
Angela P. Presson,
Namshin Kim,
Dong Sung An,
Irvin S. Y. Chen,
Sanggu Kim
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay9206
Subject(s) - repopulation , rna interference , human immunodeficiency virus (hiv) , gene , biology , lentivirus , virology , stem cell , computational biology , genetics , haematopoiesis , rna , viral disease
A novel approach enables a direct comparison of anti-HIV– and non–gene-modified stem-cell engraftment in an HIV-1–infected host.
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