Open AccessSynthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells
Author(s) -
Seung Ho Shin,
Ji Su Lee,
Jiamin Zhang,
Sungbin Choi,
Žarko Bošković,
Ran Zhao,
Mengqiu Song,
Rui Wang,
Jie Tian,
MeeHyun Lee,
Jae Hwan Kim,
Minju Jeong,
JungHyun Lee,
Michael Petukhov,
Sam W. Lee,
Sang Gyun Kim,
Lee Zou,
Sanguine Byun
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay9131
Subject(s) - mtorc1 , dna damage , synthetic lethality , dna repair , cancer research , cancer cell , biology , cancer , phenotype , microbiology and biotechnology , pi3k/akt/mtor pathway , dna , genetics , signal transduction , gene
Cancer cells with high mTORC1 activity rely on the RUVBL1/2-TTT pathway for survival, thereby providing a therapeutic window.
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