Functional validity, role, and implications of heavy alcohol consumption genetic loci | Zendy

Andrew Thompson | Zendy; James P. Cook | Zendy; Hélène Choquet | Zendy; Eric Jorgenson | Zendy; Jie Yin | Zendy; Tarja Kinnunen | Zendy; Jeff W. Barclay | Zendy; Andrew P. Morris | Zendy; Munir Pirmohamed | Zendy

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Functional validity, role, and implications of heavy alcohol consumption genetic loci

Author(s) -

Andrew Thompson,

James P. Cook,

Hélène Choquet,

Eric Jorgenson,

Jie Yin,

Tarja Kinnunen,

Jeff W. Barclay,

Andrew P. Morris,

Munir Pirmohamed

Publication year - 2020

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aay5034

Subject(s) - adh1b , genetics , genetic architecture , snp , biology , genome wide association study , population , genetic association , gene , computational biology , single nucleotide polymorphism , phenotype , medicine , genotype , environmental health , branched chain alpha keto acid dehydrogenase complex , biochemistry , dehydrogenase , enzyme

We identify six genetic loci associated with heavy alcohol intake in humans, and provide functional validation in C. elegans .

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