Open AccessENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation
Author(s) -
Chenghao Guo,
Zhuanzhuan Che,
Junjie Yue,
Peng Xie,
Shaohua Hao,
Wei Xie,
Zhuojuan Luo,
Chengqi Lin
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay4858
Subject(s) - elongation , biophysics , phase (matter) , chemistry , microbiology and biotechnology , computational biology , biology , materials science , ultimate tensile strength , metallurgy , organic chemistry
SEC can compartmentalize P-TEFb via LLPS from the inactive soluble HEXIM1 complex to regulate rapid transcriptional events.
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