Open AccessLEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells
Author(s) -
Gary LeRoy,
Ozgur Oksuz,
Nicolas Descostes,
Yuki Aoi,
Rais A. Ganai,
Havva Ortabozkoyun,
Jia-Ray Yu,
ChulHwan Lee,
James M. Stafford,
Ali Shilatifard,
Danny Reinberg
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay3068
Subject(s) - nucleosome , chromatin , transcription factor , transcription (linguistics) , microbiology and biotechnology , biology , computational biology , genetics , chemistry , biophysics , dna , gene , linguistics , philosophy
Chromatin-bound LEDGF and HDGF2 proteins allow RNAPII to overcome the nucleosome-induced block to transcription.
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