Open AccessLEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells
Author(s) -
Gary LeRoy,
Ozgur Oksuz,
Nicolas Descostes,
Yuki Aoi,
Rais Ahmad Ganai,
Havva Ortabozkoyun Kara,
Jia Yu,
Chul-Hwan Lee,
James M. Stafford,
Ali Shilatifard,
Danny Reinberg
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay3068
Subject(s) - biology , microbiology and biotechnology , transcription factor , nucleosome , transcription (linguistics) , rna polymerase ii , chromatin , gene , genetics , gene expression , promoter , linguistics , philosophy
Chromatin-bound LEDGF and HDGF2 proteins allow RNAPII to overcome the nucleosome-induced block to transcription.