Open AccessA chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application
Author(s) -
Ryosuke Ueki,
Satoshi Uchida,
Naoto Kanda,
Naoki Yamada,
Ayaka Ueki,
Momoko Akiyama,
Kazuko Toh,
Horacio Cabral,
Shinsuke Sando
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay2801
Subject(s) - in vivo , agonistic behaviour , oligonucleotide , growth factor , microbiology and biotechnology , dna , computational biology , receptor , pharmacology , biology , chemistry , cancer research , medicine , biochemistry , psychiatry , aggression
This study identifies an oligonucleotide that activates a growth factor receptor and exerts its antiapoptotic activity in vivo.
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