Open AccessB cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
Author(s) -
Huoqun Gan,
Tian Shen,
Daniel P. Chupp,
Julia R. Taylor,
Helia N. Sanchez,
Xin Li,
Zhenming Xu,
Hong Zan,
Paolo Casali
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay2793
Subject(s) - epigenetics , histone , epigenetic regulation of neurogenesis , histone methyltransferase , gene expression , antibody , cell , microbiology and biotechnology , chemistry , biology , biochemistry , genetics , gene
Sirt1 mediates epigenetic modulation of B cell AID expression and antibody response by deacetylating histones, Dnmt1 and NF-κB p65.
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