Open AccessAneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
Author(s) -
Mihriban Karaayvaz,
Rebecca E. Silberman,
Adam Langenbucher,
Srinivas Vinod Saladi,
Kenneth N. Ross,
Elena Zarcaro,
Andrea Desmond,
Murat Yıldırım,
Varunika Vivekanandan,
Hiranmayi Ravichandran,
Ravindra Mylavagnanam,
Michelle C. Specht,
Sridhar Ramaswamy,
Michael S. Lawrence,
Angelika Amon,
Leif W. Ellisen
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay2611
Subject(s) - haploinsufficiency , dna damage , aneuploidy , mutation , genetics , biology , dna , cancer research , chromosome , phenotype , gene
Normal breast epithelia fromBRCA2 mutation carriers display DNA damage and attenuated checkpoint responses.
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