Open AccessControl of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458
Author(s) -
Yu-Fan Chen,
Yi-Shuan J. Li,
ChihHung Chou,
Men Yee Chiew,
HsienDa Huang,
Jennifer HuiChun Ho,
Shu Chien,
Oscar K. Lee
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aay0264
Subject(s) - microbiology and biotechnology , long non coding rna , matrix (chemical analysis) , biology , stiffness , induced pluripotent stem cell , rna , lineage (genetic) , computational biology , chemistry , embryonic stem cell , genetics , gene , physics , chromatography , thermodynamics
Mechanical cues from matrix stiffness regulate endodermal fate of pluripotent stem cells via the long noncoding RNA 000458.
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