Open AccessZika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis
Author(s) -
Jia Zhou,
Xiaojing Chi,
Min Cheng,
XingYao Huang,
Xiuying Liu,
Jingjing Fan,
Hua Xu,
Tianli Lin,
Lei Shi,
ChengFeng Qin,
Wei Yang
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax7142
Subject(s) - homeostasis , transporter , fatty acid , microbiology and biotechnology , docosahexaenoic acid , chemistry , biology , biochemistry , polyunsaturated fatty acid , gene
Both the endothelial transporter Mfsd2a and docosahexaenoic acid uptake are disrupted in Zika virus–induced microcephaly models.
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