Open AccessThe mechanism of Hsp90-induced oligomerizaton of Tau
Author(s) -
Sabrina Weickert,
Magdalena Wawrzyniuk,
Laura John,
Stefan Rüdiger,
Malte Drescher
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax6999
Subject(s) - mechanism (biology) , hsp90 , computational biology , neuroscience , chemistry , biology , heat shock protein , epistemology , philosophy , biochemistry , gene
The chaperone Hsp90 remodels the structural ensemble of Tau, resulting in the formation of potentially neurotoxic oligomers.
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