Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation
Author(s) -
Kirsten S. Evonuk,
Ryan E. Doyle,
Carson E. Moseley,
Ian M. Thornell,
Keith Adler,
Amanda M. Bingaman,
Mark O. Bevensee,
Casey T. Weaver,
Booki Min,
Tara M. DeSilva
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax5936
Subject(s) - ampa receptor , glutamate receptor , neuroprotection , multiple sclerosis , neuroscience , oligodendrocyte , experimental autoimmune encephalomyelitis , microglia , myelin , neuroinflammation , chemistry , biology , microbiology and biotechnology , receptor , central nervous system , immunology , inflammation , biochemistry
Decreased AMPA receptor signaling on myelin selectively reduces loss of myelinated axons in autoimmune neuroinflammation.
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