Open AccessParallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells
Author(s) -
Jorge A. Zepeda-Martínez,
Carina Pribitzer,
Jingkui Wang,
Daniel Bsteh,
S. Golumbeanu,
Qing Zhao,
Thomas R. Burkard,
Brian Reichholf,
Suhn K. Rhie,
Julian Jude,
Hagar F. Moussa,
Johannes Zuber,
Oliver Bell
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax5692
Subject(s) - embryonic stem cell , biology , prc2 , stem cell , lineage (genetic) , gene , microbiology and biotechnology , genetics , epigenetics , histone h3
Stem cell identity is maintained by diverse Polycomb complexes cooperating to ensure robust silencing of key developmental genes.
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