Open AccessThe deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor
Author(s) -
Hai-Lian Bi,
Xiaoli Zhang,
Yunlong Zhang,
Xin Xie,
Yunlong Xia,
Jie Du,
HuiHua Li
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax4826
Subject(s) - epidermal growth factor receptor , cardiac hypertrophy , deubiquitinating enzyme , muscle hypertrophy , epidermal growth factor , microbiology and biotechnology , receptor , cancer research , medicine , biology , ubiquitin , gene , genetics
UCHL1 positively regulates cardiac hypertrophy via stabilizing EGFR and highlighting it as a yet unknown therapeutic target.
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