Open AccessHigh-speed AFM reveals accelerated binding of agitoxin-2 to a K + channel by induced fit
Author(s) -
Ayumi Sumino,
Takashi Sumikama,
Takayuki Uchihashi,
Shigetoshi Oiki
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aax0495
Subject(s) - biophysics , molecular dynamics , chemistry , dissociation (chemistry) , docking (animal) , binding site , dissociation constant , scorpion toxin , crystallography , scorpion , biochemistry , venom , biology , computational chemistry , receptor , medicine , nursing
We revealed that binding of agitoxin-2 to a K+ channel uses an induced-fit pathway by single-molecule analysis via high-speed AFM.
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