Open AccessInhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination
Author(s) -
Youhui Si,
Fan Zhao,
Pavani Beesetty,
Daniela Weiskopf,
Zhaotao Li,
Qiaomu Tian,
MariaLuisa Alegre,
Alessandro Sette,
Anita S. Chong,
Christopher P. Montgomery
Publication year - 2020
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaw7713
Subject(s) - immunodominance , major histocompatibility complex , biology , vaccination , immunology , staphylococcus aureus , immune system , immunity , antibody , virology , mhc class i , t cell , microbiology and biotechnology , genetics , bacteria
MHC restriction determines whetherS. aureus infection elicits protection, but vaccine efficacy is unconstrained by MHC haplotype.
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