Open AccessMechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
Author(s) -
Jan Félix,
Katharina Weinhäupl,
Christophe Chipot,
François Dehez,
Audrey Hessel,
Diego F. Gauto,
Cécile Morlot,
Olga Abián,
Irina Gutsche,
Adrián VelázquezCampoy,
Paul Schanda,
Hugo Fraga
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aaw3818
Subject(s) - allosteric regulation , mechanism (biology) , active site , protease , chemistry , microbiology and biotechnology , biochemistry , biology , enzyme , philosophy , epistemology
We decipher how an allosteric inhibitor activates the ClpP protease machinery by binding to the catalytic site.
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