Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering | Zendy

Johan M. S. van der Schoot | Zendy; Felix L. Fennemann | Zendy; Michael Valente | Zendy; Yusuf Dölen | Zendy; Iris M. Hagemans | Zendy; Anouk M.D. Becker | Zendy; Camille M. Le Gall | Zendy; Duco van Dalen | Zendy; Alper Çevirgel | Zendy; Jaco A. C. van Bruggen | Zendy; Melanie Engelfriet | Zendy; Tomislav Čaval | Zendy; Arthur E. H. Bentlage | Zendy; Marieke F. Fransen | Zendy; Maaike Nederend | Zendy; Jeanette H.W. Leusen | Zendy; Albert J. R. Heck | Zendy; Gestur Vidarsson | Zendy; Carl G. Figdor | Zendy; Martijn Verdoes | Zendy; Ferenc A. Scheeren | Zendy

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Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Author(s) -

Johan M. S. van der Schoot,

Felix L. Fennemann,

Michael Valente,

Yusuf Dölen,

Iris M. Hagemans,

Anouk M.D. Becker,

Camille M. Le Gall,

Duco van Dalen,

Alper Çevirgel,

Jaco A. C. van Bruggen,

Melanie Engelfriet,

Tomislav Čaval,

Arthur E. H. Bentlage,

Marieke F. Fransen,

Maaike Nederend,

Jeanette H.W. Leusen,

Albert J. R. Heck,

Gestur Vidarsson,

Carl G. Figdor,

Martijn Verdoes,

Ferenc A. Scheeren

Publication year - 2019

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aaw1822

Subject(s) - isotype , antibody , hybridoma technology , computational biology , phage display , recombinant dna , biology , crispr , in vivo , protein engineering , antibody repertoire , effector , monoclonal antibody , immunology , gene , genetics , biochemistry , enzyme

We develop a universal platform for CRISPR/HDR-engineering of hybridomas to obtain functionally diverse antibody panels.

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