Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo | Zendy

Dali Wang | Zendy; Jiaqi Lin | Zendy; Fei Jia | Zendy; Xuyu Tan | Zendy; Yuyan Wang | Zendy; Xiaoya Sun | Zendy; Xueyan Cao | Zendy; Fangyuan Che | Zendy; Hao Lü | Zendy; Ximing Gao | Zendy; Jackson Christopher Shimkonis | Zendy; Zifiso Nyoni | Zendy; Xueguang Lu | Zendy; Ke Zhang | Zendy

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Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

Author(s) -

Dali Wang,

Jiaqi Lin,

Fei Jia,

Xuyu Tan,

Yuyan Wang,

Xiaoya Sun,

Xueyan Cao,

Fangyuan Che,

Hao Lü,

Ximing Gao,

Jackson Christopher Shimkonis,

Zifiso Nyoni,

Xueguang Lu,

Ke Zhang

Publication year - 2019

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aav9322

Subject(s) - ethylene glycol , small interfering rna , in vivo , rna interference , gene silencing , rna , peg ratio , conjugate , recombinant dna , nuclease , chemistry , biophysics , combinatorial chemistry , materials science , biology , dna , gene , biochemistry , organic chemistry , microbiology and biotechnology , mathematical analysis , mathematics , finance , economics

Bottlebrush-structured PEG substantially enhances the pharmacokinetics of conjugated siRNA and RNAi activity in vivo.

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