Open AccessPrior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms
Author(s) -
Mark Borris D. Aldonza,
Jayoung Ku,
JiYoung Hong,
Donghwa Kim,
Seung Jung Yu,
Min-Seok Lee,
Monica Celine Prayogo,
Stephanie Tan,
Dayeon Kim,
Jinju Han,
Sang Kook Lee,
Sung Gap Im,
Han Suk Ryu,
Yoosik Kim
Publication year - 2020
Publication title -
science advances
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aav7416
Subject(s) - persistence (discontinuity) , paclitaxel , resistance (ecology) , acquired resistance , medicine , biology , drug resistance , cancer , ecology , microbiology and biotechnology , engineering , geotechnical engineering
Paclitaxel failure promotes collateral resistance to EGFR-targeted therapy by adaptive rewiring of the cellular stress response.
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