Open AccessTargeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
Author(s) -
Shih-Hsun Chen,
Xiaochun Yu
Publication year - 2019
Publication title -
science advances
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aav4340
Subject(s) - parp inhibitor , poly adp ribose polymerase , dna repair , dna , cancer research , dna damage , computational biology , biology , chemistry , microbiology and biotechnology , genetics , polymerase
A novel PARG inhibitor traps DNA repair factors at DNA lesions and selectively kills tumor cells with DNA repair defects.
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