Open AccessNo evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication
Author(s) -
Giorgio Bozzi,
Francesco R. Simonetti,
Sarah A. Watters,
Elizabeth M. Anderson,
M. Gouzoulis,
Mary F. Kearney,
Paula Rote,
Christoph Lange,
Wei Shao,
Robert J. Gorelick,
Brandie Fullmer,
Sheila Kumar,
Stephen A. Wank,
Stephen M. Hewitt,
David E. Kleiner,
Junko Hattori,
Michael J. Bale,
S. Hill,
Jennifer A. Bell,
Catherine Rehm,
Zehava Grossman,
Robert Yarchoan,
Thomas S. Uldrick,
Frank Maldarelli
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aav2045
Subject(s) - human immunodeficiency virus (hiv) , antiretroviral therapy , compartmentalization (fire protection) , virology , replication (statistics) , antiretroviral agents , medicine , biology , viral load , biochemistry , enzyme
Long-term persistence, not ongoing virus replication, is primarily responsible for maintaining HIV during antiretroviral therapy.
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