Open AccessEfficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7
Author(s) -
Scott McComb,
Pik Ki Chan,
Anna Guinot,
Holmfridur Hartmannsdottir,
Silvia Jenni,
Maria Pamela Dobay,
JeanPierre Bourquin,
Beat Bornhäuser
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aau9433
Subject(s) - effector , upstream (networking) , apoptosis , microbiology and biotechnology , caspase , caspase 8 , caspase 3 , computer science , biology , telecommunications , genetics , programmed cell death
Caspase-3 and -7 are redundantly required to amplify the extrinsic and intrinsic apoptotic cascade in human leukemia.
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