Open AccessA methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair
Author(s) -
Weizhe Li,
Hongyan Wang,
Xiaolu Zhao,
Hongguo Duan,
Binghua Cheng,
Yafei Liu,
Mengjie Zhao,
WenJie Shu,
Yu-Chao Mei,
Zengqi Wen,
Mingliang Tang,
Lin Guo,
Guohong Li,
Qiang Chen,
Xiaoqi Liu,
HaiNing Du
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aau7566
Subject(s) - plk1 , microbiology and biotechnology , dna damage , phosphorylation , kinase , dna repair , function (biology) , dna pkcs , dna methylation , cancer research , biology , dna , chemistry , genetics , protein kinase a , cancer , cell cycle , gene , gene expression
Two types of small-group modifications on Plk1 control its activity and its cellular functions.
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