Open AccessRestriction of hepatitis B virus replication by c-Abl–induced proteasomal degradation of the viral polymerase
Author(s) -
Lidan Hou,
Jie Zhao,
Shaobing Gao,
Tong Ji,
Tianyu Song,
Yining Li,
Jingjie Wang,
Chenlu Geng,
Min Long,
Jiang Chen,
Hui Lin,
Xiujun Cai,
Yong Cang
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aau7130
Subject(s) - hepatitis b virus , virology , ubiquitin ligase , cullin , biology , viral replication , hepatitis b virus pre beta , proteasome , ubiquitin , viral entry , virus , cancer research , hepatitis b virus dna polymerase , microbiology and biotechnology , genetics , gene
c-Abl inhibits replication of hepatitis B virus by promoting CRL4Cdt2 -mediated destruction of the viral polymerase.
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