Open AccessCryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain
Author(s) -
Janna M. Bigalke,
Shintaro Aibara,
Robert Roth,
Göran Dahl,
Euan Gordon,
Sarah Dorbéus,
Alexey Amunts,
Jenny Sandmark
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aau4202
Subject(s) - cysteine , computational biology , domain (mathematical analysis) , microbiology and biotechnology , biology , chemistry , biochemistry , mathematical analysis , mathematics , enzyme
We report the first subnanometer resolution structure of the RET extracellular domain in complex with a ligand and co-receptor.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom