Open AccessA molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds
Author(s) -
Haigang Song,
Niels S. van der Velden,
Sally L. Shiran,
Patrick Bleiziffer,
Christina Zach,
Ramon Sieber,
Aman S. Imani,
Florian Krausbeck,
Markus Aebi,
Michael F. Freeman,
Sereina Riniker,
Markus Künzler,
James H. Naismith
Publication year - 2018
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aat2720
Subject(s) - peptide bond , chemistry , peptide , nucleophile , scissile bond , amide , stereochemistry , delocalized electron , lone pair , protease , enzyme , organic chemistry , biochemistry , molecule , catalysis
We report the structure of a fungal enzyme that activates the amide bond, allowing nucleophilic chemistry.
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