Open AccessCorrelation of quantitative dynamic contrast‐enhanced MRI with microvascular density in necrotic, partial necrotic, and viable liver tumors in a rabbit model
Author(s) -
Moon Jungwon,
Kim JaeHun,
Choi Dongil,
Yang Jehoon,
Lee Min Woo,
Choi YoonLa,
Rhim, MD Hyunchul
Publication year - 2016
Publication title -
journal of applied clinical medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.83
H-Index - 48
ISSN - 1526-9914
DOI - 10.1120/jacmp.v17i5.6314
Subject(s) - magnetic resonance imaging , pathology , dynamic contrast , correlation , dynamic contrast enhanced mri , nuclear medicine , medicine , chemistry , radiology , mathematics , geometry
The purpose of this study was to examine the correlation of quantitative dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) with microvessel density (MVD) in necrotic, partial necrotic, and viable tumors using a rabbit VX2 liver tumor model. Nine rabbits were used for this study. The complete necrotic area (CNA), partial necrotic area (PNA), and viable tumor area (VTA) of liver tumors were experimentally induced by radiofrequency ablation (RFA). DCE‐MRI data were processed based on the extended Kety model to estimateK trans , v eand v p parameters. The boundaries among CNA, PNA, and VTA were delineated based on H&E stain images, and MVD was assessed for each subregion of each VX2 tumor based. There were no correlations between ph‐parameters ( K trans , v e , andv p ) and MVD for CNA. For PNA, theK transvalues were positively correlated with the MVD ( r = 0.8124 , p < 0.0001 ). For VTA, we found a positive correlation betweenK transvalues and the MVD ( r = 0.5743 , p < 0.05 ). Measuring from both the PNA and the VTA, meanK transvalues were positively correlated with mean MVD ( r = 0.8470 , p < 0.0001 ). In a rabbit VX2 liver tumor model,K transvalues correlated well with MVD counts of PNA and VTA in liver tumors. PACS number(s): 87.19.If MRI