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Anthropomorphic 1 H MRS head phantom
Author(s) -
Rice J. Robin,
Milbrandt Rodney H.,
Madsen Ernest L.,
Frank Gary R.,
Boote Evan J.,
Blechinger Joseph C.
Publication year - 1998
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.598306
Subject(s) - imaging phantom , metabolite , biomedical engineering , in vivo , head (geology) , materials science , relaxation (psychology) , nuclear medicine , nuclear magnetic resonance , chemistry , medicine , physics , biology , paleontology , biochemistry , microbiology and biotechnology
An anthropomorphic1 H MRS head phantom has been developed which mimics the in vivo structure, metabolite concentrations, and relaxation times (for both water and metabolites) of human brain tissue. Different brain regions and two tumor types, fluid‐containing ventricles, an air‐filled sinus, and subcutaneous fat are all simulated. The main tissue‐mimicking materials are gelatin/agar mixtures with metabolites and several other ingredients added. Their composition and method of production are thoroughly described. T 1 's and T 2 's of water in the phantom are very close to in vivo values, and metabolite T 1 's and T 2 's are considerably more realistic than those in aqueous solutions. Spectra and relaxation times for the pig brain were also acquired and compare well with those of the phantom. The realistic properties of this phantom should be useful for testing spectral quantitation and localization.