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Frequency‐domain spectroscopy and imaging of tissue and tissue‐simulating media
Author(s) -
Pogue Brian W.
Publication year - 1996
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.597765
Subject(s) - imaging phantom , optics , materials science , optical tomography , photon diffusion , spectroscopy , medical imaging , absorption (acoustics) , tomographic reconstruction , tomography , light scattering , fluorescence spectroscopy , scattering , biomedical engineering , fluorescence , physics , computer science , medicine , light source , quantum mechanics , artificial intelligence
The goal of this work was to develop and study the use of a diagnostic in vivo tissue spectroscopy system based upon frequency‐domain light measurements. Intensity‐modulated light which is incident upon a scattering sample creates waves of light intensity which propagate through the medium in a manner which is dependent upon the scattering and absorption characteristics of the tissue. These waves can be used to recover these optical interaction parameters using a diffusion model of light propagation in tissue. This method can be used to quantify chromophores for dosimetry in therapeutic laser treatments or for diagnostic medical applications. The theoretical modeling for diffuse fluorescence signals was also developed and experimentally tested in a tissue‐simulating phantom with excellent agreement, suggesting that fluorescence lifetime or quantum yield can be made from tissue. Preliminary work was done on an optical tomography algorithm using measurements of phase and intensity at multiple points on a tissue surface to reconstruct images of the optical properties of the interior. The development of a tomographic imaging system was examined in the final section of this thesis with data from a tissue simulating phantom.