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Errors in cerebral blood flow determinations by xenon‐enhanced computed tomography due to estimation of arterial xenon concentrations
Author(s) -
Good Walter F.,
Gur David,
Yonas Howard,
Herron John M.
Publication year - 1987
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.596051
Subject(s) - xenon , cerebral blood flow , nuclear medicine , computed tomography , isotopes of xenon , blood flow , cerebrovascular circulation , biomedical engineering , medicine , physics , radiology , anesthesia , nuclear physics
Errors in the determination of xenon concentrations in arterial blood during inhalation of xenon–oxygen mixtures are used to assess errors in the derivation of regional cerebral blood flow by the xenon‐enhanced computed tomography (CT) method. The results of this study indicate that approximating the arterial buildup by a single exponential introduces relatively small errors in estimated flow values. The most significant systematic error is introduced by errors in estimation of the xenon arrival time to the brain in relationship to sequential (CT) scanning times.