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Subtraction of simultaneously acquired dual radionuclide images
Author(s) -
Sloboda R. S.
Publication year - 1986
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.595837
Subject(s) - subtraction , normalization (sociology) , image subtraction , radionuclide , nuclear medicine , computer science , gamma camera , biomedical engineering , artificial intelligence , algorithm , medical physics , computer vision , image processing , mathematics , physics , medicine , image (mathematics) , binary image , arithmetic , sociology , anthropology , quantum mechanics
The physical aspects of a simultaneous dual radionuclide technique incorporating computer subtraction for the diagnosis of infection using 6 7 Ga citrate and 99 m Tc methylene diphosphonate (MDP) or sulfur colloid are considered. The efficacy of the data acquisition protocol and the interpretation of the subtracted images are shown to depend significantly on fundamental imaging system parameters. Measurement of these parameters using simple phantoms and their role in elucidating the technique is detailed. Subtracted images produced by three variations of the basic method arising from different normalization algorithms in current usage are compared. Simple phantoms are again used in assessing the accuracy of each variation. Clinical results are reported elsewhere.