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Digital background subtraction for fluorescence imaging
Author(s) -
Profio A. Edward,
Balchum Oscar J.,
Carstens Felix
Publication year - 1986
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.595836
Subject(s) - background subtraction , subtraction , fluorescence , image subtraction , medical imaging , artificial intelligence , contrast (vision) , computer vision , background image , nuclear medicine , image processing , computer science , optics , medicine , physics , image (mathematics) , mathematics , pixel , binary image , arithmetic
A method of enhancing contrast in fluorescence imaging has been devised, based on real‐time digital subtraction of a background video image from a signal‐plus‐background video image. Color filters are used to differentiate signal from background. The technique has been applied to detection of small tumors labeled with the tumor specific fluorescent drug hematoporphyrin derivative.