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Transition metal–chelate complexes as relaxation modifiers in nuclear magnetic resonance
Author(s) -
Brown Mark A.,
Johnson G. Allan
Publication year - 1984
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.595455
Subject(s) - chelation , nuclear magnetic resonance , relaxation (psychology) , metal , magnetic resonance imaging , spin–lattice relaxation , chemistry , transition metal , materials science , inorganic chemistry , physics , nuclear quadrupole resonance , organic chemistry , medicine , psychology , social psychology , radiology , catalysis
Studies are reported of relaxation modifiers for use in nuclear magnetic resonance (NMR) imaging systems. Chelate complexes of transition metal salts are under investigation to determine their ability to reduce the spin–lattice relaxation time ( T 1 ) of the nucleus under observation and to reduce the toxicity of the metal ion. The ethylenediaminetetraacetate (EDTA) complexes of FeCl 3 , GdCl 3 , and MnCl 2 are not as effective as the respective salts in reducing T 1 of water protons at 90 MHz. For Mn, this diminution in ability is offset by a significant reduction in toxicity. Explanations for this loss of effectiveness are discussed.