z-logo
Premium
Use of the Clinac‐35 for tissue activation in noninvasive measurement of capillary blood flow
Author(s) -
Nussbaum Gilbert H.,
Purdy James A.,
Granda Conrad O.,
Emami Bahman,
Sapareto Stephen A.
Publication year - 1983
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.595395
Subject(s) - capillary action , beam (structure) , blood flow , linear particle accelerator , cathode ray , perfusion , materials science , yield (engineering) , acceleration , biomedical engineering , nuclear medicine , chemistry , electron , radiochemistry , optics , physics , medicine , nuclear physics , radiology , classical mechanics , metallurgy , composite material
Through adjustment of operating parameters responsible for the acceleration, steering, and focusing of electrons en route to the target, we have extracted a 30‐MV x‐ray beam from the Clinac‐35 linear accelerator that is suitable for use in photon activation − 1 5 O decay studies of tissue perfusion. This beam is significantly more efficient than the “standard” 25‐MV beam in producing 1 5 O in situ through activation of tissue oxygen, thereby substantially reducing the dose to tissue required to yield a desired initial 1 5 O activity. Production and characteristics of the higher energy beam are discussed, and data obtained from its application to measurement of capillary blood flow in animal tumors are presented and analyzed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here