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Use of the Clinac‐35 for tissue activation in noninvasive measurement of capillary blood flow
Author(s) -
Nussbaum Gilbert H.,
Purdy James A.,
Granda Conrad O.,
Emami Bahman,
Sapareto Stephen A.
Publication year - 1983
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.595395
Subject(s) - capillary action , beam (structure) , blood flow , linear particle accelerator , cathode ray , perfusion , materials science , yield (engineering) , acceleration , biomedical engineering , nuclear medicine , chemistry , electron , radiochemistry , optics , physics , medicine , nuclear physics , radiology , classical mechanics , metallurgy , composite material
Through adjustment of operating parameters responsible for the acceleration, steering, and focusing of electrons en route to the target, we have extracted a 30‐MV x‐ray beam from the Clinac‐35 linear accelerator that is suitable for use in photon activation − 1 5 O decay studies of tissue perfusion. This beam is significantly more efficient than the “standard” 25‐MV beam in producing 1 5 O in situ through activation of tissue oxygen, thereby substantially reducing the dose to tissue required to yield a desired initial 1 5 O activity. Production and characteristics of the higher energy beam are discussed, and data obtained from its application to measurement of capillary blood flow in animal tumors are presented and analyzed.