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Transient cavitation in tissues during ultrasonically induced hyperthermia
Author(s) -
Sommer F. Graham,
Pounds Douglas
Publication year - 1982
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.595065
Subject(s) - cavitation , ultrasonic sensor , ultrasound , transducer , materials science , transient (computer programming) , hyperthermia , diagnostic ultrasound , biomedical engineering , acoustics , medicine , physics , computer science , operating system
An isospherical array of ultrasonic transducers designed for hyperthermia treatment of malignant tumors in humans was employed in studies of transient cavitation in tissues during ultrasonic heating. Both in vitro and in vivo studies revealed the presence of transient cavitation within tissues during ultrasonic heating, as indicated by the detection of the first half‐order subharmonic of insonifying ultrasound with an interrogating transducer. The applied power to the focal region of the array required to exceed cavitation thresholds in tissue was 75±8 W/cm 2 , a level considerably higher than that required to heat tissues to the temperature range used for cancer treatment (43–45 °C.).