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Laser fluorescence bronchoscope for localization of occult lung tumors
Author(s) -
Profio A. Edward,
Doiron Daniel R.,
King E. G.
Publication year - 1979
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.594617
Subject(s) - hematoporphyrin , image intensifier , fluorescence , optics , materials science , laser , autofluorescence , nuclear medicine , chemistry , photodynamic therapy , medicine , physics , organic chemistry
A system for imaging occult bronchogenic carcinoma by the fluorescence of previously‐injected, tumor‐specific compound hematoporphyrin‐derivative has been assembled and successfully used to locate a tumor l mm thick. The violet excitation source is a krypton ion laser coupled to fused quartz fiber light conductor. An electrostatic image intensifier attached to a standard flexible fiberoptic bronchoscope provides a bright image even at relatively low irradiance. A red secondary filter rejects most reflected background and autofluorescence. Sensitivity and contrast capability of the system should permit detection of a tumor less than 0.1 mm thick.