Premium
Poster ‐ 01: LabPET II Pixelated APD‐Based PET Scanner for High‐Resolution Preclinical Imaging
Author(s) -
Lecomte Roger,
Arpin Louis,
Beaudoin JeanFrançois,
Bergeron Mélanie,
Bouchard Jonathan,
Bouziri Haithem,
Cadorette Jules,
Gaudin Émilie,
Jürgensen Nadia,
Koua Konin Calliste,
Trépanier PierreYves Lauzier,
Leroux JeanDaniel,
LoigHoule Francis,
Njejimana Larissa,
Paillé Maxime,
Paulin Caroline,
Pepin Catherine,
Pratte JeanFrançois,
Samson Arnaud,
Thibaudeau Christian,
Viscogliosi Nicolas,
Fontaine Réjean
Publication year - 2016
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4961775
Subject(s) - lyso , detector , scanner , image resolution , optics , imaging phantom , physics , full width at half maximum , pixel , scintillator
Purpose: LabPET II is a new generation APD‐based PET scanner designed to achieve sub‐mm spatial resolution using truly pixelated detectors and highly integrated parallel front‐end processing electronics. Methods: The basic element uses a 4×8 array of 1.12×1.12 mm 2 Lu 1.9 Y 0.1 SiO 5 :Ce (LYSO) scintillator pixels with one‐to‐one coupling to a 4×8 pixelated monolithic APD array mounted on a ceramic carrier. Four detector arrays are mounted on a daughter board carrying two flip‐chip, 64‐channel, mixed‐signal, application‐specific integrated circuits (ASIC) on the backside interfacing to two detector arrays each. Fully parallel signal processing was implemented in silico by encoding time and energy information using a dual‐threshold Time‐over‐Threshold (ToT) scheme. The self‐contained 128‐channel detector module was designed as a generic component for ultra‐high resolution PET imaging of small to medium‐size animals. Results: Energy and timing performance were optimized by carefully setting ToT thresholds to minimize the noise/slope ratio. ToT spectra clearly show resolved 511 keV photopeak and Compton edge with ToT resolution well below 10%. After correction for nonlinear ToT response, energy resolution is typically 24±2% FWHM. Coincidence time resolution between opposing 128‐channel modules is below 4 ns FWHM. Initial imaging results demonstrate that 0.8 mm hot spots of a Derenzo phantom can be resolved. Conclusion: A new generation PET scanner featuring truly pixelated detectors was developed and shown to achieve a spatial resolution approaching the physical limit of PET. Future plans are to integrate a small‐bore dedicated mouse version of the scanner within a PET/CT platform.